Over the past ten years, third space endoscopy has seen tremendous change. It describes the endoscopic operations carried out in the region of the gastrointestinal system between the muscularis mucosae and muscularis propria. Currently, it offers a wide variety of potential uses, including the treatment of motility problems, the removal of submucosal malignancies, and the management of diverticulae. Creating a submucosal tunnel, carrying out the required surgery, and repairing the mucosal flaws constitute the fundamental approach used during third space endoscopic procedures. The most typical third space endoscopy operation is per oral endoscopic myotomy (POEM). The foundation of third space endoscopy, also known as submucosal endoscopy, is the idea that the deeper layers of the GI tract may be reached by tunneling in the submucosal space without endangering the integrity of the mucosa above. For the patient, third space endoscopy is a minimally invasive procedure. It requires extremely sophisticated techniques that have essentially replaced many common surgical procedures. While still upholding the same standards as previous surgical treatments, the approach should result in quicker recovery periods.
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