Third space endoscopy, commonly referred to as submucosal endoscopy, is founded on the principle that the deeper layers of the gastrointestinal (GI) tract can be accessed by tunneling in the submucosal space without compromising the integrity of the overlying mucosa. Third-space endoscopy is minimally invasive for the patient. It involves highly specialized, procedures that have largely supplanted many conventional surgical interventions. The process should lead to faster recovery times while still meeting the same standards as other surgical procedures. Peroral endoscopic myotomy is one of the many innovative techniques within the field of third-space endoscopy. Other procedures, including endoscopic submucosal dissection, and submucosal tunneling endoscopic resection, are examples of third-space endoscopic procedures used for treating early cancers in the gastrointestinal tract.
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